Systemic inflammation promotes erythrocyte sequestration
نویسندگان
چکیده
منابع مشابه
Erythrocyte-derived microvesicles amplify systemic inflammation by thrombin-dependent activation of complement.
OBJECTIVE Transfusion of aged blood has been associated with increased morbidity and mortality in critically ill patients. During storage, erythrocytes release increasing numbers of microvesicles (red blood cell-derived microvesicles [RBC-MV]). We hypothesized that RBC-MV mediate some of the deleterious effects of aged blood transfusions. APPROACH AND RESULTS We established a murine transfusi...
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ژورنال
عنوان ژورنال: Critical Care
سال: 1999
ISSN: 1364-8535
DOI: 10.1186/cc494